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Saúde / 24/05/2021

COVID 19 NEWS

Japanese identify protein that prevents Covid replication

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Japanese identify protein that prevents Covid replication

Fonte Hokkaido University / News Medical

A team of scientists the University of Hokkaido, led by Professor Akinori Takaoka of the Institute of Genetic Medicine, showed that RIG-I, a biological molecule that detects RNA viruses, restricts the replication of SARS-CoV-2 in human lung cells.

The finding may help even patients with chronic obstructive pulmonary disease - COPD, including bronchitis and emphysema, a risk factor for Covid-19.

The team, who works at Hokkaido University in Japan, recorded the finding in a study, published on May 11 in the journal Nature Immunology.

Defense

In other words, scientists at Hokkaido University have discovered a new defensive response to SARS-CoV-2 that involves the viral pattern recognition receptor RIG-I.

Microbial pathogens in our body are detected by proteins called pattern recognition receptors (PRRs), which also trigger immune responses to these pathogens.

Viral infections are detected by a subset of PRRs; scientists have focused their attention on the RIG-I protein, which belongs to this subset.

RIG-I is known to be critical for the detection and response to RNA viruses, such as the influenza virus.

Experiments

In experiments carried out on cell culture lines, scientists found that there was little innate immune response to SARS-CoV-2 in lung cells, suggesting that the signaling pathway leading to the immune response was aborted.

However, viral replication has been suppressed.

Scientists investigated the role of RIG-I and found that its deficiency caused an increase in viral replication. Other experiments confirmed that suppression of viral replication was dependent on RIG-I.

Additional work should be done to discover factors or conditions that modulate RIG-I expression levels and may lead to new strategies to control SARS-CoV-2 infection.

Blocks replication

"We found that RIG-I protein levels can be significantly regulated in a dose-dependent manner after treatment with tretinoin in these cells derived COPD patients," explain the researchers in the research.

Scholars believe that RIG-I slows down replication of the coronavirus due to a structural element it carries called the helicase domain.

It interacts with the wrongdoer's genetic material and blocks an enzyme responsible for making “copies” of the virus, called polymerase.


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